The Duke of York relinquishes his title as York's Duke.
Prince Andrew is giving up his honors, among them the Duke of York, he has stated in a personal statement.
He has been under mounting attention over his connections with disgraced financier Jeffrey Epstein, with requests for the royal household to take steps against him.
That now seems to have resulted in the prince deciding to voluntarily hand back his titles and to give up involvement of the prestigious order.
In his message he said he continued to "firmly refute the claims against me".
"In consultation with the King, and my direct and wider family, we have decided the continued claims about me take away from the work of His Majesty and the Royal Family," said a message from Prince Andrew.
"I have chosen, as I always have, to put my obligation to my family and nation first.
"I support my choice five years ago to step back from official duties.
"With the monarch's agreement, we feel I must now go a additional measure. I will therefore no longer hold my title or the honours which have been conferred upon me. As I have said earlier, I vigorously refute the allegations against me."
He has faced a series of controversies, among them a legal case he resolved with an accuser, inquiries about his finances and his association with an alleged intelligence operative.
He will remain a member of royalty - but will cease to be the York's Duke, a honor granted from his mother, the late Queen Elizabeth.
Andrew had already ended to be a "working royal" and had lost the use of his His Royal Highness designation and no longer appeared at public engagements. His role now will be even more reduced.
His previous partner will be known as Sarah Ferguson and no longer Duchess of York, but their daughters will carry on to have the honor of princess.
The royal has faced strong scrutiny over his connections with notorious figure Jeffrey Epstein, more in recent times including doubts about when he had actually ended contact.
In his television appearance, the royal had said that he had ended all links with Jeffrey Epstein after they had been photographed together in the city in the end of 2010.
But messages sent in February 2011 later surfaced indicating that the prince had privately continued in communication with Epstein, such as swapping a message: "Remain connected and we'll meet again soon!"
There had been mounting frustration in the royal household at the controversies that remained to plague the figure.
In the coming days a posthumous memoir by the accuser will be published which is expected to draw more focus on his connection with the plaintiff and the financier.